Target-controlled infusions/patient-controlled sedation

The control of administration of drugs such as propofol is a task that is difficult to master. Two approaches to this task have emerged—target-controlled infusion, and patient-controlled sedation. In the first, a set point for drug in a hypothetical effect site is specified, and the controller delivers drug to hold the predicted concentration at that level. In the second, the patient administers small boluses of drug to maintain comfort. The theoretical basis of these approaches will be reviewed, available technology presented, and practical use of these devices discussed.

Keywords: Target-controlled infusion, Patient-controlled sedation, Propofol, Sedation